[Antihypoxic action of orotic acid]. / Antikhipoksichnoto deistvie na orotova kiselina.

The authors examined the effect of the ortonic acid in comparison with several preparations from various pharmacologic groups on models of complete ischemia, obtained by decapitation and hypobaric hypoxia in mice. The ortonic acid showed strong anti-hypoxic effect in these two models. The results revealed that the strongest effect manifested the ortonic acid, followed by vinponcetine and cinarizine, in mice with hypoxia, induced by decapitation and by the method of hypobaric hypoxia. Hexobarbital-sodium and papaverine showed comparatively weaker effect, but xantional nicotinate - the slightest. A wide spectrum od drugs, known by experimental and clinical data as antihypoxic drugs allowed the authors to accept the models as relative and the conclusion for the effect of the ortonic acid was considered as significant. They assume that vascular and metabolism effect participates in the mechanism of the antihypoxic action of the ortonic acid.

[Use of the Soviet preparation methindione for injections in convulsive conditions]. / Primenenie pri sudorozhnykh sostoianiiakh otechestvennogo preparata metindiona dlia in"ektsii

The author studied the action of a Soviet preparation Metindion in 22 patients with serial epileptic seizures and in 16 patients with an epileptic status. The studies demonstrated a high anticonvulsive activity in serial fits. In epileptical states the action of metindion was less expressed. Its combination with diazepam preparations and barbiturates appeared to have a more expressed and prolonged anticonvulsive action. Metindion is most effective when used at initial stages of a convulsive condition.

Influence of tricyclic antidepressant drugs on experimental arterial hypertension.

The tricyclic antidepressant drugs: imipramine, opipramol, amitryptiline and nortryptiline inhibit development of experimental arterial hypertension in rats.